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NEW: March 2018

PhD student and technician position in cancer biology:

“Uncovering the genetics of Wee1 inhibitor treatment”

 

Working environment:

We have two exciting opportunities for a PhD student and a technician, funded by the Dutch Cancer Society (KWF). The PhD position will be for 4 years, and should results in a PhD thesis at the University of Groningen. Our lab participates in the Cancer Research Center Groningen (CRCG), which is part of the Graduate School for Medical Sciences. Within the graduate school, you have the opportunity to follow high-quality courses throughout your PhD training.

Our research is focused on cell cycle regulation and DNA damage responses in the context of cancer. The research group is embedded in the Department of Medical Oncology of the University Medical Center Groningen (UMCG) in the Netherlands, where oncological patient care is coordinated with preclinical and fundamental research on the biology and treatment of cancer. The lab is surrounded by other labs that study chromatin biology and genome instability.

Background:

You will work on a project aiming to elucidate the genetic factors that determine whether cancer cells respond to Wee1 inhibition. The current project is part of a consortium, in which the University of Groningen (UMCG: Marcel van Vugt, Steven de Jong), the University of Utrecht (UMCU: Wigard Kloosterman) and the Netherlands Cancer Institute (NKI/AvL: Thijn Brummelkamp, Jan Schellens, Jos Jonkers) collaborate.

Using a combination of genetic screens, mouse models, cell biology and whole genome analysis of patient samples, we aim to uncover the genetic factors that determine sensitivity of cancers for Wee1 inhibition. Initially, this project focuses on ovarian cancers, but other cancers with similar genetic characteristics will be included in our analyses.

Your profile:

We offer a PhD studentship and a position for a technician to ambitious candidates with a passion for DNA damage signaling, molecular cell biology, genetic screens, and overall cancer biology. The PhD candidate should have the following requirements:

  • MSc in (Molecular/Medical) Biology.
  • Fluent in English, both spoken and written.
  • A background in molecular cell biology is essential.
  • Experience with genetic screens is very useful.
  • Experience in cell cycle or DNA damage signaling, microscopy or genetics is appreciated.
  • An enthusiastic, ambitious team player.

 

The technician candidate should have the following requirements:

  • BSc in (Molecular/Medical) Biology.
  • Experience in a research lab setting
  • Hands-on experience in molecular cell biological techniques
  • A certificate to perform animal experiments (art. 12 or 9) is highly recommended.

For more information, please contact me at:

m.vugt_@_umcg_._nl (remove all underscores)

 

 

beyond these positions, we are constantly interested in enthusiastic PhD students and post-docs, and frequently have projects available for MSc or BSc students. We would like to encourage and support applications for personal fellowships, including those by EMBO, FEBS, Marie Curie and HFSP. Please contact me trough email at m.vugt-at-umcg.nl for inquiries. Links to relevant fellowship programs are below:

European Organisation for Molecular Biology (EMBO)

Human Frontiers Science Program (HFSP)

Federation of European Biochemical Societies (FEBS)

Marie Curie Actions