Contact / Jobs

we are constantly interested in enthusiastic PhD students and post-docs, and frequently have projects available for MSc or BSc students. We would like to encourage and support applications for personal fellowships, including those by EMBO, FEBS, Marie Curie and HFSP. Please contact me trough email at m.vugt-at-umcg.nl for inquiries. Links to relevant fellowship programs are below:

European Organisation for Molecular Biology (EMBO)

Human Frontiers Science Program (HFSP)

Federation of European Biochemical Societies (FEBS)

Marie Curie Actions

 

UPDATE May 17th 2017:

 

PhD student position in cancer biology:

“targeting replication stress in cancer cells”

 

Working environment:

We have an exciting opportunity for a PhD student, funded by the European Research Council (ERC). The position will be for 4 years, and should results in a PhD thesis at the University of Groningen. Our lab participates in the Cancer Research Center Groningen (CRCG), which is part of the Graduate School for Medical Sciences. Within the graduate school, you have the opportunity to follow high-quality courses throughout your PhD training.

The PhD student position is available in the research group of prof. Marcel van Vugt, which is focused on cell cycle regulation and DNA damage responses in the context of cancer. The research group is embedded in the Department of Medical Oncology of the University Medical Center Groningen (UMCG) in the Netherlands, where oncological patient care is coordinated with preclinical and fundamental research on the biology and treatment of cancer. The lab is surrounded by other labs that study chromatin biology and genome instability.

Background:

You will work on a project aiming to elucidate how cancer cells can cope with high levels of replication stress. A characteristic of many cancers is their high degree of genomic instability, which is thought to be fueled by replication stress. In this project, which is funded by a recently awarded ERC consolidator grant, we aim to unravel how oncogene-induced replication stress is resolved throughout the cell cycle, with a particular focus on mitosis. You will use biochemical microscopy and genetic approaches. Within this project, we, will ultimately validate our findings in patient material and ex vivo cultures of primary tumor material.

Your profile:

We offer a PhD studentship to an ambitious candidate with a passion for DNA damage signaling and cell cycle biology. The candidate should have the following requirements:

  • MSc in (Molecular/Medical) Biology.
  • Fluent in English, both spoken and written.
  • A background in molecular cell biology is essential.
  • Experience in cell cycle or DNA damage signaling, microscopy or genetics is appreciated.
  • An enthusiastic, ambitious team player.
  • the project is aimed to start in summer 2017.

What we offer:

  • A full-time contract (36 hours/week) for 4 year, after one year an evaluation is conducted.
  • The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

More information

For more information about this vacancy you may contact:
 Marcel van Vugt at m.vugt@umcg.nl

Select Reading:

Heijink AM et al. A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. PNAS 2015. 8;112(49):15160-5.

Hengeveld RC et al. Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability. Dev Cell. 2015. 34(4):466-74.

Fehrmann RS et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet. 2015. 47(2):115-25.

Lafranchi L et al. APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. EMBO J. 2014. 33(23):2860-79.